Herpes simplex virus 1 and 2 HSV-1 and HSV-2also known by their taxonomical names Human alphaherpesvirus 1 and Human alphaherpesvirus 2are two members of the human Herpesviridae familya set of viruses that produce viral infections in the majority of humans. They can be spread when an infected person begins shedding the virus. Many of those who are infected never develop symptoms. Sometimes, the viruses cause mild or atypical symptoms during outbreaks. However, they can also cause more troublesome forms of herpes simplex.
WHO response to herpes (HSV-1 and HSV-2)
Preventing acquisition of a new genital herpes infection is particularly important for women in late pregnancy, as this is when the risk for neonatal herpes is greatest. Additional research is underway to develop more effective prevention methods against HSV infection, such as vaccines. Several candidate Dormant vaccines are currently being studied. HSV-2 infection is widespread throughout the world and is almost exclusively sexually transmitted, causing genital herpes.
HSV-2 is the main cause of genital herpes, which can also be caused by herpes simplex virus type 1 HSV Contagious with HSV-2 is herpes and incurable. Genital herpes caused by HSV-2 is a global issue, and an estimated million people worldwide were living with the infection in Prevalence of HSV-2 infection was estimated to be highest in Africa It simplex also shown to increase with age, though the highest numbers of people newly-infected were adolescents.
More women are when with HSV-2 than men; in it was estimated that million women and million men were living with the infection.
This is because sexual transmission of HSV is more efficient from men to women than from women to men. Genital herpes infections often have no symptoms, or mild symptoms that go unrecognised. Most infected people are unaware that they have the infection. When symptoms do occur, genital herpes is characterised by one or more genital or anal contagoius or simplex sores called ulcers.
In addition to genital ulcers, symptoms of new genital herpes infections often include fever, body aches, and swollen lymph nodes. After an initial genital herpes infection with HSV-2, recurrent symptoms are common but often less severe than the first outbreak. The frequency of outbreaks tends to decrease over time. Herpes infected with HSV-2 dormant experience sensations of mild tingling or shooting pain in the legs, hips, and buttocks before the occurrence of genital ulcers.
HSV-2 is mainly transmitted during sex, through contact with genital when, skin, sores or fluids zimplex someone infected with the virus. HSV-2 can be transmitted from skin ls the genital or anal area that looks normal cpntagious is often transmitted in the absence of symptoms.
In simplex circumstances, HSV-2 infection can be transmitted from a mother to her infant during delivery. Infection with HSV-2 in people living with HIV and other immunocompromised individuals often has a more severe presentation and more frequent recurrences.
In advanced HIV disease, HSV-2 can lead to more serious, but rare, complications such as meningoencephalitis, esophagitis, id, pneumonitis, retinal necrosis, or disseminated infection.
Recurrent symptoms of genital herpes may be painful and the infection can lead to social stigma and psychological distress. These factors can contagious an dormant impact on quality heerpes life and sexual relationships. However, in time, most people with herpes adjust to contagious with the infection. Antivirals, such as acyclovir, famciclovir, and valacyclovir are the most effective medications available for people infected with HSV.
Individuals with genital HSV infection herpes abstain from sexual activity whilst experiencing symptoms of genital herpes. HSV-2 contqgious most contagious during when outbreak of sores, but can also be transmitted when no symptoms are felt or visible.
The consistent and correct use of condoms can help reduce the risk of spreading genital herpes.
However, condoms only provide partial protection, as HSV can be found in areas not covered by herpes condom. Additional research is underway to develop contagious effective prevention methods against HSV infection, such as vaccines or topical microbicides compounds which can be applied inside the vagina or rectum to protect against qhen transmitted infections.
When and partners are working to accelerate research to develop new strategies shen prevention and control of genital and neonatal HSV-1 and HSV-2 infections. Such research includes the development of HSV vaccines and topical microbicides. Several candidate vaccines and microbicides are currently being studied. Herpes simplex virus 31 January Key facts The herpes simplex virus, or herpes, is categorized into 2 types: herpes simplex virus type 1 HSV-1 and herpes simplex virus type 2 HSV HSV-2 is a sexually transmitted infection that causes genital herpes.
An estimated 3. Most oral and genital herpes infections are asymptomatic. Symptoms of dlrmant include painful blisters or ulcers at the site of infection. Herpes infections are most contagious when symptoms are present but can still be transmitted to others in the absence of symptoms. This article is about the human viruses. For for the genus of animalian simplex viruses, see Simplexvirus. Main article: Herpes simplex. Play media. Please expand the article to include this information.
Further details may exist on the talk page. May Main article: Oncolytic herpes virus. Main article: Viral neuronal tracing. Sherris Medical Microbiology 4th ed. Dormant Hill. Pediatr Rev. World Health Organization. December 11, Retrieved September 22, Genital herpes is common in the United States.
More than one out of every six people aged 14 to 49 years have genital simplex. Infectious Diseases in Obstetrics and Gynecology. Retrieved J R Soc Interface. J Clin Invest. Sex Transm Dis. Annual Review of Medicine. New England Journal of Medicine. Retrieved 16 July Virus Res.
ACS Infectious Diseases. Bibcode : PNAS. FEBS Journal. Journal of Virology.
Acta Virol. Cell Res. Cell Cycle. Human Herpesviruses. Cambridge University Press. Future Virology. July Bibcode : PLoSO Infect Genet Evol. Mol Biol Evol doi : The Journal of Infectious Diseases. Antiviral Research. Retrieved 30 October Infection, Genetics and Evolution. Mutation Research. Cancer Research. Cancer Gene Therapy. November 18, Neuroscience and Biobehavioral Reviews. Avian Diseases. Role of Herpesvirus in Artherogenesis.
Trichomoniasis Trichomonas vaginalis. Infectious skin disease : Viral cutaneous conditions, including viral exanthema B00—B09— Herpes simplex Herpetic whitlow Herpes gladiatorum Herpes simplex keratitis Herpetic sycosis Neonatal herpes simplex Herpes genitalis Herpes labialis Eczema herpeticum Herpetiform esophagitis. B virus infection. Chickenpox Herpes zoster Herpes zoster oticus Ophthalmic zoster Disseminated herpes zoster Zoster-associated pain Modified varicella-like syndrome.
KSHV Kaposi's sarcoma. BPV Equine sarcoid.
Herpes simplex virus - Wikipedia
Parvovirus B19 Erythema infectiosum Reticulocytopenia Papular purpuric gloves and socks syndrome. Merkel cell polyomavirus Merkel cell carcinoma. MeV Measles. Rubella virus Rubella Congenital rubella syndrome "German measles" Alphavirus infection Chikungunya fever.
Taxonomy of the Herpesvirales. RaHV-1 2 3. SalHV-1 2 3. Herpesviridae IgHV MuHV-1 2 8. ElHV-1 4 5. Baltimore virus classification. I: dsDNA viruses. Myoviridae Podoviridae Siphoviridae. Alloherpesviridae Herpesviridae Malacoherpesviridae.
Lipothrixviridae Rudiviridae. II: ssDNA viruses. Arteriviridae Coronaviridae Mesoniviridae Roniviridae. Alphaflexiviridae Betaflexiviridae Gammaflexiviridae Tymoviridae. V: — ssRNA viruses primarily helical. Bornaviridae Filoviridae Nyamiviridae Paramyxoviridae Rhabdoviridae.
STD Facts - Genital Herpes (Detailed version)
Arenaviridae Ophioviridae Orthomyxoviridae genera : Deltavirus. Metaviridae Pseudoviridae Retroviridae. Caulimoviridae Hepadnaviridae. Categories : Paraphyletic groups Simplexviruses Unaccepted virus taxa Sexually transmitted diseases and infections.
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Human alphaherpesvirus 1 Human alphaherpesvirus 2. 115 other Simplexvirus spp. E3 ubiquitin ligase that activates viral gene transcription by opposing chromatinization of the viral genome and counteracts intrinsic- and interferon -based antiviral responses. Neurovirulence factor. Binds to BECN1 and inactivates autophagy.
Herpes simplex virus
P P Uracil-DNA glycosylase. Portal protein U L Twelve of these proteins constitute the capsid portal ring through which DNA enters and exits the capsid. DNA virus helicase-primase complex -associated protein. Replication origin -binding protein. Alkaline exonuclease.
Serine - threonine protein kinase.